Yahoo explains the whole thing’s origin:

[T]he man in the photo is New York’s Zeddie Little, 25, who was taking part in the Cooper River Bridge 10k run, which was held on March 31, in Charleston, South Carolina.

Medical University of South Carolina (MUSC) systems analyst Will King, who was just taking a seemingly random photograph of runners in the middle of the race, snapped the photo and uploaded it to his Flickr account.

“One of my friends commented on the picture and said something along the lines of ‘I dub this guy Mr. Ridiculously Photogenic,'” King said. “I thought it was a pretty cool comment, so I posted it on Reddit. For some reason it just took off from there.”

And QuickMeme has captioned responses.